Bda Library Medline Search Liquorice and Dentistry

In Turkey, Ankaferd Blood Stopper() (ABS) has been approved for the management of external haemorrhages and bleedings occurring during dental surgeries (Goker et al., 2008). Ankaferd comprises a standardized mixture of plants, including Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica diodica. This study aimed to evaluate the efficacy of AB S tam ponade in the control of intra-operative bleeding occurring during ad enoidectomy performed in children under the age of 12. Sixty children were randomized to receive 1 to 5 minute-tamponade with either ABS or topical gauze sponges soaked in saline solution (SS) during their ad enoidectomy.. Time-to-haemostasis and the number of packs required were recorded. A visual analog scale was used by the operating surgeon to record subjective data, including the rate of bleeding following the first adenoid pack removal (0= none, 3=brisk). Compared to the children in the SS group (n=30), time-to-haemostasis seen in ABS patients (n=30) was significantly shorter (mean +/standard deviation, 1.93 +/1.39 min vs 3.20 +/1.50 min; p<0.0001); they required a lower number of packs (mean, 1.93 vs. 3.20), and appeared to bleed less (53.3% vs 6.7%; p=0.0001). ABS aids in the control of intra-operative bleeding and reduces the number of packs required to achieve haemostasis, so that it can be recommended for tamponades per formed during paediatric adenoidectomies. Publication Type Evaluation Studies. Journal Article. Date Created 20120601 BDA LIBRARY MEDLINE SEARCH LIQUORICE AND DENTISTRY To request copies of any of these articles please use one of our request forms. Articles can be emailed or posted for a charge of £2.50 each. Year of Publication 2011 <23> Unique Identifier 21449211 Status MEDLINE Authors Hu CH; He J; Eckert R; Wu XY; Li LN; Tian Y; Lux R; Shuffer JA; Gelman F; Mentes J; Spackman S; Bauer J; Anderson MH; Shi WY. Authors Full Name Hu, Chu-Hong; He, Jian; Eckert, Randal; Wu, Xiao-Yang; Li, Li-Na; Tian, Yan; Lux, Renate; Shuffer, Justin A; Gelman, Faina; Mentes, Janet; Spackman, Sue; Bauer, Janet; Anderson, Maxwell H; Shi, Wen-Yuan. Institution Hu,Chu-Hong. School of Dentistry, University of California, Los Angeles, USA. Title Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria. Source International Journal of Oral Science. 3(1):13-20, 2011 Jan. Other ID Source: NLM. PMC3469870 Abstract Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. Publication TypeDental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20110331 Year of Publication 2011 <24> Unique Identifier 20722535 Status MEDLINE Authors La VD; Tanabe S; Bergeron C; Gafner S; Grenier D. Authors Full Name La, Vu Dang; Tanabe, Shin-ichi; Bergeron, Chantal; Gafner, Stefan; Grenier, Daniel. Institution La,Vu Dang. Faculty of Dentistry, Laval University, Quebec City, QC, Canada. Title Modulation of matrix metalloproteinase and cytokine production by licorice isolates licoricidin and licorisoflavan A: potential therapeutic approach for periodontitis. Source Journal of Periodontology. 82(1):122-8, 2011 Jan. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND: Inflammatory cytokines and matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in the tissue destruction observed in periodontitis, which is a disease that affects toothsupporting structures. In the present study, we investigate the effects of licorice-derived licoricidin (LC) and licorisoflavan A (LIA) on the secretion of various cytokines and MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) lipopolysaccharide (LPS). METHODS: Macrophages were treated with non-toxic concentrations of LC or LIA before being stimulated with A. actinomycetemcomitans LPS. The secretion of cytokines and MMPs and the activation of nuclear factor-kappa B (NF-kappaB) p65 and activator protein (AP)-1 were assessed by enzyme-linked immunosorbent assays. RESULTS: LC and LIA inhibited the secretion of interleukin (IL)-6 and chemokine (C-C motif) ligand 5 in a concentration-dependent manner but did not affect the secretion of IL-8 by LPS-stimulated macrophages. LC and LIA also inhibited the secretion of MMP-7, -8, and -9 by macrophages. The suppression of cytokine and MMP secretion by LC and LIA was associated with the reduced activation of NF-kappaB p65 but not that of AP-1. CONCLUSION: The present study suggests that LC and LIA have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMPmediated disorders such as periodontitis. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20101229 Year of Publication 2011 BDA LIBRARY MEDLINE SEARCH LIQUORICE AND DENTISTRY To request copies of any of these articles please use one of our request forms. Articles can be emailed or posted for a charge of £2.50 each. <25> Unique Identifier 20812941 Status MEDLINE Authors Badr AE; Omar N; Badria FA. Authors Full Name Badr, A E; Omar, N; Badria, F A. Institution Badr,A E. Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. Title A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament. Source International Endodontic Journal. 44(1):51-8, 2011 Jan. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract AIM: To evaluate the antibacterial and cytotoxic effects of Liquorice as a root canal medicament and to compare its action to the commonly used root canal medicament calcium hydroxide Ca(OH)(2). METHODOLOGY: The antibacterial effect of Liquorice and Ca(OH)(2) either separately or in combination was investigated against Enterococcus faecalis. Agar-well diffusion methods, broth microdilution tests and biofilm susceptibility assays were used to determine the antibacterial activity. Human periodontal ligament fibroblast tissue culture was used to assess the cytotoxicity of the preparations under investigation. RESULTS: Liquorice extract either by itself or in combination with Ca(OH)(2) had a significant inhibitory effect against Enterococcus faecalis compared with that of Ca(OH)(2) alone. The use of Liquorice extract followed by Liquorice/Ca(OH)(2) mixture retained significantly more viable periodontal ligament cells than Ca(OH)(2) , which had a strong lethal effect on the cells. CONCLUSION: Liquorice extract either separately or as Liquorice/Ca(OH)(2) mixture had a potent bactericidal effect against Enterococcus faecalis and retained compatibility with fibroblasts in tissue culture compared to the commonly used root canal medicament Ca(OH)(2).Copyright © 2010 International Endodontic Journal. Publication Type Comparative Study. Evaluation Studies. Journal Article. Date Created 20101207 Year of Publication 2011 <26> Unique Identifier 21108917 Status MEDLINE Authors Peters MC; Tallman JA; Braun TM; Jacobson JJ. Authors Full Name Peters, M C; Tallman, J A; Braun, T M; Jacobson, J J. Institution Peters,M C. Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, 1100 N University, Ann Arbor, MI 48109, USA. [email protected] Title Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study. Source European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry. 11(6):274-8, 2010 Dec. Abstract AIM: To determine the clinical effect of a simple herbal caries-prevention protocol aimed at reduction of Streptococcus mutans (SM) in young children in a pre-school setting. STUDY DESIGN: Proof-of-principle pilot study. METHODS: To prove the concept this pilot study delivered a clinical intervention using sugar-free lollipops containing liquorice root extract. Regimen: Supervised herbal lollipops, twice daily for 3 weeks. Species-specific monoclonal antibody testing of saliva provided SM counts. Children were grouped in high, medium and low caries-risk using baseline SM-levels as risk-indicator. Bacterial numbers at baseline, during intervention, and for 9 weeks postintervention were compared. STATISTICS: SM levels were analysed using GEE modelling. RESULTS: High-risk children showed the steepest early decrease in mean log-SM (P<.001). At end of a follow-up period, the log-SM decrease moved the high-risk group down to moderate-risk level. High-risk children showed a decrease in fitted mean SM% not seen in other groups (P<.001). The decrease reached a nadir around 22-days post-intervention. Twice-daily use of herbal lollipop significantly reduced both number and relative percent of SM in high-risk children. SM numbers were reduced for 22 days after the last lollipop, stabilized and then began to rebound. BDA LIBRARY MEDLINE SEARCH LIQUORICE AND DENTISTRY To request copies of any of these articles please use one of our request forms. Articles can be emailed or posted for a charge of £2.50 each. CONCLUSION: A potential for simple effective caries-prevention for high-risk children has been demonstrated. Encouraging results warrant randomised clinical trials (RCT) of liquorice root in herbal lollipops or alternative modes of delivery. Publication Type Clinical Trial. Comparative Study. Journal Article. Research Support, Non-U.S. Gov't. Date Created 20101126 Year of Publication 2010 <27> Unique Identifier 20682015 Status MEDLINE Authors Sasaki H; Suzuki N; Alshwaimi E; Xu Y; Battaglino R; Morse L; Stashenko P. Authors Full Name Sasaki, H; Suzuki, N; Alshwaimi, E; Xu, Y; Battaglino, R; Morse, L; Stashenko, P. Institution Sasaki,H. Department of Cytokine Biology, The Forsyth Institute, Boston, MA, USA Pulp Biology and Endodontics, Graduate School, Tokyo Medical and Dental University, Bunkyoku, Tokyo, Japan. Title 18beta-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-kappaB inactivation in interleukin-10-deficient mice. Source Journal of Periodontal Research. 45(6):757-63, 2010 Dec. Other ID Source: NLM. NIHMS254198 Source: NLM. PMC3075584 Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND AND OBJECTIVE: 18beta-Glycyrrhetinic acid (GA) is a natural antiinflammatory compound derived from licorice root extract (Glycyrrhiza glabra). The effect of GA on experimental periodontitis and its mechanism of action were determined in the present study. MATERIAL AND METHODS: Periodontitis was induced by oral infection with Porphyromonas gingivalis W83 in interleukin-10-deficient mice. The effect of GA, which was delivered by subcutaneous injections in either prophylactic or therapeutic regimens, on alveolar bone loss and gingival gene expressions was determined on day 42 after initial infection. The effect of GA on lipopolysaccharide (LPS)-stimulated macrophages, T cell proliferation and osteoclastogenesis was also examined in vitro. RESULTS: 18beta-Glycyrrhetinic acid administered either prophylactically or therapeutically resulted in a dramatic reduction of infection-induced bone loss in interleukin-10-deficient mice, which are highly disease susceptible. Although GA has been reported to exert its antiinflammatory activity via downregulation of 11beta-hydroxysteroid dehydrogenase-2 (HSD2), which converts active glucocorticoids to their inactive forms, GA did not reduce HSD2 gene expression in gingival tissue. Rather, in glucocorticoid-free conditions, GA potently inhibited LPS-stimulated proinflammatory cytokine production and RANKL-stimulated osteoclastogenesis, both of which are dependent on nuclear factor-kappaB. Furthermore, GA suppressed LPSand RANKL-stimulated phosphorylation of nuclear factor-kappaB p105 in vitro. CONCLUSION: These findings indicate that GA inhibits periodontitis by inactivation of nuclear factor-kappaB in an interleukin-10and glucocorticoid-independent fashion.Copyright © 2010 John Wiley & Sons A/S. Publication Type Journal Article. Research Support, N.I.H., Extramural. Date Created 20101022 Year of Publication 2010 <28> Unique Identifier 20930349 Status MEDLINE Authors Mohire NC; Yadav AV. Authors Full Name Mohire, Nitin C; Yadav, Adhikrao V. Institution Mohire,Nitin C. Department of Pharmacy, Government College of Pharmacy, Vidyanagar, Karad, DistrictSatara, Maharashtra, India. [email protected] Title Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Source Indian Journal of Dental Research. 21(3):380-4, 2010 Jul-Sep. Abstract OBJECTIVE: The objective of the present work was to develop chitosan-based polyherbal toothpaste and evaluate its plaque-reducing potential and efficacy in reduction of dental pathogens. MATERIALS AND METHODS: Antimicrobial activity of herbal extracts against dental pathogens were performed by using disk diffusion method. The pharmaceutical evaluation of toothpaste was carried out as per the US Government Tooth Paste Specifications. A 4-week clinical study was conducted in patients with oro-dental problems to evaluate the plaque BDA LIBRARY MEDLINE SEARCH LIQUORICE AND DENTISTRY To request copies of any of these articles please use one of our request forms. Articles can be emailed or posted for a charge of £2.50 each. removing efficacy of chitosan-based polyherbal toothpaste with commercially available chlorhexidine gluconate (0.2% w/v) mouthwash as positive control. Total microbial count was carried out to determine the percentage decrease in the oral bacterial count over the period of treatment. RESULT: Herbal extracts were found to possess satisfactory antimicrobial activity against most of the dental pathogens. Chitosan-containing polyherbal toothpaste significantly reduces the plaque index by 70.47% and bacterial count by 85.29%, and thus fulfills the majority of esthetic and medicinal requirements of oral hygiene products. CONCLUSION: Chitosan-based polyherbal toothpaste proves itself as a promising novel oral hygiene product as compared with currently available oral hygiene products. A further study to confirm the exact mechanism and active constituents behind antiplaque and antimicrobial activity of chitosan-based polyherbal toothpaste and its efficacy in large number of patient population is on high demand. Publication Type Clinical Trial. Comparative Study. Journal Article. Research Support, Non-U.S. Gov't. Date Created 20101008 Year of Publication 2010 <29> Unique Identifier 20690419 Status MEDLINE Authors Xu YZ; Qiu YL; An ZG; Yang FY. Authors Full Name Xu, Yan-zhi; Qiu, Yong-le; An, Zhi-guang; Yang, Feng-ying. Institution Xu,Yan-zhi. Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [email protected] Title Role of the Chinese herbal medicine xianhuayin on the reversal of premalignant mucosal lesions in the golden hamster buccal pouch. Source International Journal of Oral Science. 2(1):53-8, 2010 Mar. Other ID Source: NLM. PMC3475595 Abstract AIM: To investigate the role of the Chinese herbal medicine Xianhuayin on the reversal of 7,12-dimethylbenz[a]anthracene (DMBA)-induced premalignant mucosal lesions in the oral buccal pouch of golden hamsters. METHODOLOGY: The animals were randomly divided into a non-diseased control group (n=5) and an experimental group including 50 animals in which the buccal mucosa had been painted with DMBA (0.5% in acetone) to generate an oral mucosa premalignant lesion. Animals in the experimental group were further divided into Xianhuayin-treated group (n=30), untreated premalignant lesion group (n=10) and normal saline (NS)-treated group (n=10). The cheek (buccal) pouch mucosa of the golden hamsters in each group was observed with light and electron microscopy eight weeks after intragastric administration with NS or Xianhuayin. RESULTS: In the non-diseased control group, the buccal mucosa was keratinized and stratified squamous epithelium under a light microscope. In the untreated premalignant lesion group, variable degrees of epithelial dysplasia was observed. The irregular epithelial mucosa gradually became distinct in the Xianhuayin-treated group. Scanning electronic microscopic (SEM) analysis showed that surface of the cells exhibited honeycomb structures in the hamster of untreated-group. The cells were morphologically irregular, overlapped and loosened in the untreated premalignant lesion group. Most of the cell surface exhibited honeycomb structure in the Xianhuayin-treated group. Transmission electronic microscopic (TEM) analysis showed that buccal mucosal epithelial cells were morphologically regular in the non-diseased control group. Desmosomes and tonofibrils were reduced and the nucleus was morphologically irregular in the untreated premalignant lesion group. In the Xianhuayintreated group, the widening intercellular gap was gradually reduced, desmosomes and the cells becoming morphologically regular. No significant difference was observed between the hamsters in NS-treated group and those in the untreated premalignant lesion group. Significant therapeutic efficacy was observed in the group receiving Xianhuayin. CONCLUSION: Xianhuayin is effective in the reversal of DMBA-induced premalignant lesions in the buccal pouch of golden hamsters. Publication Type Comparative Study. Journal Article. Research Support, Non-U.S. Gov't. Date Created 20100809 Year of Publication 2010 <30> Unique Identifier 20098971 Status MEDLINE Authors Baykul T; Alanoglu EG; Kocer G. Authors Full Name Baykul, Timucin; Alanoglu, E Guchan; Kocer, Gulperi. Institution Baykul,Timucin. Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Suleyman Demirel, Isparta, Turkey. [email protected] BDA LIBRARY MEDLINE SEARCH LIQUORICE AND DENTISTRY To request copies of any of these articles please use one of our request forms. Articles can be emailed or posted for a charge of £2.50 each. Title Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. Source Journal of Contemporary Dental Practice [Electronic Resource]. 11(1):E088-94, 2010. Abstract AIM: To determine the efficacy of the topical application of Ankaferd Blood Stopper (ABS) on hemorrhagic diathesis following dental procedures under different conditions. BACKGROUND: Some patients have a tendency to bleed excessively after dental surgery for a variety of reasons, making oral surgical procedures more risky for these patients. Since hemorrhage can cause major morbidity and mortality, the identification of a novel, effective hemostatic agent could improve the management of excessive bleeding that occurs during dental procedures. CASE DESCRIPTIONS: Four patients (3 females, 1 male) aged 28-45 with bleeding tendencies due to different presurgical conditions such as von Willebrand Disease, chronic liver failure, and mitral valve replacement presented for tooth extraction. Hematological consultations were obtained prior to surgical intervention and their international normalized (INR) ratio values were adjusted to less than 1.5; none received clotting factor replacement. All the extractions were performed under local anesthesia with and without epinephrine. In the presence of postsurgical bleeding, the efficacy of the ampule form of topical ABS was observed. Sex, age, anamnesis, von Willebrand Factor, activated partial thromboplastin time, factor VIII, and platelet counts of patients were recorded prior to the extractions. CONCLUSIONS: ABS was found to be effective within 10 to 20 minutes in controlling bleeding in most of the patients after dental surgery. These observations suggest the use of ABS may be a beneficial hemostatic agent for use in patients with hemorrhagic diathesis following tooth extraction. Additional research is needed to clarify the role of this unique medicinal product in the surgical treatment of dental patients with bleeding tendency. CLINICAL SIGNIFICANCE: ABS has demonstrated potential for being an effective hemostatic agent for the treatment of excessive bleeding following dental surgery in four patients with hemorrhagic diathesis. Publication Type Case Reports. Journal Article. Date Created 20100125 Year of Publication